Gender–specific Association of ACE gene insertion/deletion polymorphism with Schizophrenia

Dr. V. Lakshmi; D. Sandhya Deepthi; N. Priyambika; K. Uma Jyothi

Volume : IV, Issue : VIII, August - 2015

Gender–specific Association of ACE gene insertion/deletion polymorphism with Schizophrenia

Dr. V. Lakshmi, D. Sandhya Deepthi, N. Priyambika, K. Uma Jyothi

Abstract :

Angiotensin converting enzyme (ACE) is a key enzyme in the renin angiotensin system which also modulates dopamine, a neurotransmitter and is considered as a candidate gene for schizophrenia. There is a controversy regarding the association of ACE I/D polymorphism with schizophrenia. The present case control study was conducted to examine the association between ACE I/D polymorphism and schizophrenia in the population of Andhra Pradesh. No association was found between ACE I/D polymorphism and schizophrenia. However when the samples were segregated on the basis of sex, significant over representation of D allele was observed in unaffected females which suggests its protective role.