Genetic implications in Class II subdivision 2 malocclusion in two siblings. Case report

Dana Festila; Mircea Ghergie; Alexandrina Muntean

Volume : III, Issue : VII, July - 2014

Genetic implications in Class II subdivision 2 malocclusion in two siblings. Case report

Dana Festila, Mircea Ghergie, Alexandrina Muntean

Abstract :

The aim of this study was to find genetic implication in the etiology of Class II subdivision 2 malocclusion using single nucleotide polymorphism as genetic marker in two siblings with Class II subdivision 2 malocclusion, starting from the literature�s opinions regarding the inherited patterns of this anomaly. Clinical aspects knowing as being hereditary were found out after the extra oral, intraoral and radiological examination. Genomic DNA was also extracted from the buccal mucosa of the two siblings in order to determine their genotype. Four markers were selected from each patient, MyoH1, VDR, PAX9 and RUNX2. Genetic association was found between single nucleotide polymorphism and this malocclusion for PAX9 gene. Even though genetic analyze demonstrated the hereditary etiology of the Class II subdivision 2 malocclusion, some clinical features were different in the two siblings