Genome Wide Transcriptional Analysis of  Gene Expression Signatures and Pathways  on Neoplastic Pancreatic Cancer

Anusha.B.N; Shambu.M.G; Kusum Paul

Volume : II, Issue : VIII, August - 2013

Genome Wide Transcriptional Analysis of Gene Expression Signatures and Pathways on Neoplastic Pancreatic Cancer

Anusha. B. N, Shambu. M. G, Kusum Paul

Abstract :

The neoplastic pancreatic cancer originated from both endocrine and exocrine organs shows cancer related deaths. There are various cell types with their complex interactions between tumor and non tumor cells. Extracellular matrix of pancreas show inflammation on tumor progression. The inflammation enhanced cancer progression and cellular transformation that leads to entry of cancer cells into the circulation and regulates the gene transcription. Our goal of this study on experimental data that supports inflammation in pancreatic cancer development and pathway may create an extracellular matrix that supports tumor formation. Human natural killer cells showkey effectors of innate immune response and there a function of cells is enhanced by cytokines and interleukin-2(Il-2) in inflammatory pathway (AKT, PI3K, NF-kB). Thus the pancreatic inflammatory signaling pathway with the target genes and proteins acts as a potential drug targets in the drug discovery against neoplastic pancreatic cancer. signaling pathway belongs to a complex system of communication that governs cellular process. any change in signaling cascade leads to change in cell function and causes many diseases