IJSR - International Journal of Scientific Research

Shilpa Kodge; Dr. K. H. Shivprasad; Dr. Vijayakumar Durg

Volume : VI, Issue : V, May - 2017

Green Synthesis, Characterisation and Biological Evaluation of Schiff base of Drug and its Silver Complex

Shilpa Kodge, Dr. K. H. Shivprasad, Dr. Vijayakumar Durg

Abstract :

The work presented in this paper concerns the synthesis, characterization and biological evaluation of silver complex of Schiff base synthesized from Sulfamethoxazole & m–nitro benzaldehyde by microwave irradiation followed by complexation with silver metal. The synthesized Schiff base & its silver complex have been characterized by elemental analysis, FTIR & NMR spectroscopy. Also they have been screened in vitro for their antibacterial and antifungal activities against two bacteria namely Escherichia coli & Staphylococcus aureus and two fungus Candida albicans & Aspergillus niger. The new synthesized silver complex has exhibited significant inhibition for both bacterial and fungal pathogens. Also it has been observed that incorporation of silver metal in Schiff base has reduced its MIC value without reducing the diameter of inhibition zone.