Haematological Profile in Chronically Undernourished Thrifty Rats at 28 Days of Age

M.M. Karandikar; S.M.Vaidya; K.G.Apte

Volume : V, Issue : VIII, August - 2016

Haematological Profile in Chronically Undernourished Thrifty Rats at 28 Days of Age

M. M. Karandikar, S. M. Vaidya, K. G. Apte

Abstract :

 Foetal programming due to undernutrition is a known risk factor for the worldwide epidemic of Type 2 diabetes and cardiovascular disease.Total leukocyte count (6.9 vs. 12.7x 103/μL ; p<0.0001, n=6, U vs. C) and Lymphocytes (36.5% vs. 67.7%; p<0.0001, n=6, U vs. C) was significantly lower but granulocytes was significantly higher (21.1% vs. 69.9%; p<0.0001, n=6, U vs. C ) in the undernourished colony, RBC content (7.7 vs. 9.4 x 1012/L;, p< non significant,n=6, U vs. C) Hb (11.5g/ dl vs 14.8g/dl; p<0.0001, n=6, U vs. C) and Hematocrit (39.05% vs. 47.11%; p<0.0001, n=6, U vs. C ) were less but with a high RBC distribution width (11.99 vs. 13.36,p<0.0001,n=6,U vs. C). Platelet count (424.3 vs. 602.3 x 103/microliter, p<0.001, n=6, U vs. C) and Mean platelet volume (5.9 vs. 6.1 fL p< 0.01, n=6, U vs. C) were lower in the undernourished colony. This is indicative of a state of anaemia, an inflammatory process and a hypoplastic bone marrow.