Haloperidol Versus Granisetron for  Prophylaxis of Post–Operative Nausea and  Vomiting. – A Double Blind Prospective  Randomised Study

Dr. Suhas Ramaswamy; Dr. Narendra; Dr. Madhusudan Upadya

Volume : II, Issue : IX, September - 2013

Haloperidol Versus Granisetron for Prophylaxis of Post–Operative Nausea and Vomiting. – A Double Blind Prospective Randomised Study

Dr. Suhas Ramaswamy, Dr. Narendra, Dr. Madhusudan Upadya

Abstract :

Background: Haloperidol a Butyrophenone with a high affinity for Dopamine D2 receptors has a strong antiemetic property. Materials and methods: 90 ASA I–II patients aged 18–65yrs scheduled for elective laparoscopic surgeries were randomized into three groups. Group H received Haloperidol1mg, Group G received Granisetron 1mg .Group C received no antiemetics. Anaesthesia was standardized. Recovery time, sedation level, pain score, nausea score, episodes of vomiting, rescue antiemetics,ECG and other side effects were evaluated. Results: There was no significant difference in nausea and vomiting between haloperidol group and granisetron group. Sedation score was significantly more in haloperidol compared to granisetron but recovery was not statically significant. 6 cases (20%) in granisetron group had headache, which is statistically significant. Conclusion: Haloperidol provides antiemetic protection during the peak incidence of post–operative nausea and vomiting (PONV).Antiemetic doses of haloperidol is safe.