Hb Q: An uncommon hemoglobin variant, in a native of West Bengal and Punjab  A report of two cases.

Dr.Reeta Dhar; Dr.Nitin Kadam; Dr. Smriti Dewan; Dr.Kuldeep Singh

Volume : IV, Issue : XI, November - 2015

Hb Q: An uncommon hemoglobin variant, in a native of West Bengal and Punjab A report of two cases.

Dr. Reeta Dhar, Dr. Nitin Kadam, Dr. Smriti Dewan, Dr. Kuldeep Singh

Abstract :

Hb Q– India is a rare alpha chain variant and usually it presents in heterozygous form. It is caused by the mutation AAG – GAG (Aspartic acid – histidine) in the position of codon 64 of the alpha 1 gene. In High–performance liquid chromatography (HPLC), it is seen as an unknown peak in the retention time window of 4.77 minutes � 0.02 minute. Most of the previous cases were reported in Sindhi family. Here we report two cases of HbQ India; one was 30 year old female native of West Bengal and another 22 year old female native of Punjab.