Volume : VII, Issue : III, March - 2018
HEPATITIS B VIRUS GENOTYPE AND DISEASE SEVERITY IN CHRONIC HEPATITIS B PATIENTS FROM NEW DELHI
Bibhash Nandi, Anita Chakravarti, Preena Bhalla, Premashis Kar
Abstract :
Introduction: Chronic infection with different genotypes of the hepatitis B virus (HBV) is known to affect disease progression and the clinical outcome. Information from this study will aid in gaining a better understanding of the pathogenesis of chronic hepatitis B (CHB) as well as to gauge the extent of liver damage caused by the different HBV genotypes prevalent in New Delhi.
Material and methods: In a study group of 50 HBsAg positive CHB patients, the HBV genotype was identified by using PCR–RFLP analysis of the S gene. Patients were evaluated clinically, and were subjected to various serological and histopathological investigations.
Results: The most common HBV genotype was D (31/50, 62%), followed by A (15/50, 30%) and mixed A/D genotype (4/50, 8%). Patients infected with HBV genotype D had significantly higher levels of serum viral load and a higher median histological activity index (HAI) score when compared to genotypes A and A/D (p<0.05).
Conclusions: These findings suggest that Genotypes A, D and A/D exist in CHB patients in New Delhi, and among these Genotype D is the commonest and is associated with a greater derangement of liver function.
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DOI : 10.36106/ijsr
Cite This Article:
Bibhash Nandi, Anita Chakravarti, Preena Bhalla, Premashis Kar, HEPATITIS B VIRUS GENOTYPE AND DISEASE SEVERITY IN CHRONIC HEPATITIS B PATIENTS FROM NEW DELHI, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-3 | March-2018
Number of Downloads : 161
References :
Bibhash Nandi, Anita Chakravarti, Preena Bhalla, Premashis Kar, HEPATITIS B VIRUS GENOTYPE AND DISEASE SEVERITY IN CHRONIC HEPATITIS B PATIENTS FROM NEW DELHI, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-3 | March-2018
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