Volume : VIII, Issue : II, February - 2019

Herpes Simplex Infection in Patients Living With HIV/AIDS.

Anjum M. Momin, Avani Patel

Abstract :

 

Background: Cutaneous involvement is most common in patients living with HIV/AIDS. Globally prevalence of herpes simplex infection has been increasing especially among patients with HIV. HSV–2 (herpes simplex virus–2) infection is currently the most common cause of genital ulcer disease. HSV infection may present as IRIS (Immune Reconstitution Inflammatory Syndrome) in HIV reactive patients after starting HAART (Highly Active Anti–Retroviral  Therapy).

Aims: Aim & objectives of our study were to know the prevalence and characteristics of HSV infection in patients living with HIV/AIDS and effect of anti–retroviral therapy on the course of the disease.

Methods: After obtaining informed consent, total 200 HIV reactive patients with or without herpes simplex infection were enrolled in the study. Detail history, clinical examination, required investigations were done. Apart from anti–retroviral therapy, patients were given oral acyclovir as per NACO guidelines. Results were analyzed using excel sheet.

Results: Out of 200 HIV reactive patients, 25% (50 patients) had herpes simplex infection. Majority of them were having herpes genitalis (in 88% patients out of 50). Chronic ulcerative lesion was the most common presentation. HSV infection was also seen as part of IRIS (immune reconstitution inflammatory syndrome) in some patients.

Conclusion: Infection by herpes simplex virus (HSV) is one of the most common opportunistic infection. Currently HSV–2 is the most common cause of genital ulcer disease. Treatment of herpes simplex infection by oral acyclovir as per NACO guidelines along with anti–retroviral therapy reduce the frequency of attacks, duration of symptoms, also reduce viral shedding from an individual.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

HERPES SIMPLEX INFECTION IN PATIENTS LIVING WITH HIV/AIDS., Anjum M. Momin, Avani Patel INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-2 | February-2019

Number of Downloads : 115

References :