IJSR - International Journal of Scientific Research

Dr. N Nagarajan; Dr. Jaganath A; Dr. Esha Roy; Dr.T R Pandiyan; Dr. B Sree Vaishnavi; Mr. Janakiraman P.

Volume : VIII, Issue : VIII, August - 2019

HIGH DOSAGE OF ATROPINE ADJUSTED WITH THE SEVERITY OF OP COMPOUND POISONING AND EARLY INTIATION OF INJECTION PRALIDOXIME AND INJECTION MAGNESIUM SULPHATE WITHIN 2 HOURS OF POISONING – REDUCTION OF MORTALITY NEAR TO MINIMUM IN OUR STUDY OF 250 PATIENTS WITH OP COMPOUND POISONING IN TERTIARY HOSPITAL IN PESIMSR KUPPAM.

Dr. N Nagarajan, Dr. Jaganath A, Dr. Esha Roy, Dr. T R Pandiyan, Dr. B Sree Vaishnavi, Mr. Janakiraman P.

Abstract :

Background: Organophosphorus compounds are poor man choice as suicidal poison because of the unrestricted availability and being cheaper. We have studied 250 cases of OP compound poisoning, different parameters like age, sex, rural/urban, mode of poisoning, factors associated with mortality and morbidity have been studied in our patients in ICU, PESIMSR kuppam. Material and Methods: This series of Organophosphorus poisoning cases were conducted in the department of General Medicine and ICU care, PESIMSR, Kuppam, Chittoor district, Andhra Pradesh. This is a retrospective study of 250 OP compound poisoning patients admitted between April 2012 to June 2019. Diagnosis of OP compound poisoning is based on clinical features, history of exposure to OP poison and low pseudocholinesterase activity. A standard treatment of atropine, PAM and Magnesium sulphate was used. Results: Of the 250 cases studied 55% cases (136) were male and 45% cases(114) were female,98% cases(245) were suicidal and 2% cases(5) were accidental,81%cases(203) were from rural and 19% (47)cases were from urban population, 29 patients developed intermediate syndrome and 16 died. Conclusion: The benefit of pralidoxime is significant if it is used as earlier as possible in the treatment of Organophosphorus compound poisoning. The dose of Atropine may go in increasing trends if OP poisoning is severe and the ingestion of poison is too much. Reduction of the dose of atropine in the case of OP compound poisoning is detrimental to patient and it lead to intermediate syndrome. The timely initiation of Atropine, PAM, Magnesium sulphate have prevented acute complications like pulmonary edema, heartblock ,severe adycardia.