Volume : VIII, Issue : IV, April - 2019

Histochemical Characteristics Of Mucosubstances in Adenocarcinoma of Endocervical Glands

Dr. Ajay J. Shedge, Dr. Shedge Swapna A. , Dr Mrs Padmaja A Havle, Dr. Priya Roy

Abstract :

BACKGROUND: The apical epithelial surfaces of mammalian respiratory, gastrointestinal, and reproductive tracts are coated by mucus, a mixture of water, ions, glycoproteins, proteins, and lipids.. Mucins are mainly of two types– Neutral and Acidic. OBJECTIVES: To know the mucin distribution of the endocervical glands in malignant lesions. METHODOLOGY: This is a retrospective, observational , analytical, case control study aimed to evaluate mucins histo–chemical pattern in malignant endocervical glands. Twenty five histologically proven adenocarcinoma of endocervical glands were taken. Tissue sections were stained by Mayer‘s Haematoxylin and Eosin, PAS, PAS–diastase, Phenylhydrazine–PAS, Alcian blue 2.5, Alcian Blue 1, combined Alcian blue–PAS, Aldehyde Fuschin and combined Aldehyde fuchsin– Alcian blue techniques. RESULTS: Results were tabulated according to color intensity into different grades ranging from + to ++++. Regarding mucin histochemistry of adenocarcinoma of endocervical glands –A mixture of both neutral and acidic mucins are found. Neutral mucins are in trace amount. In acidic no sialomucins but few sulphomucins are seen. CONCLUSION: Mucin histochemical patterns serve as valuable, cost–effective tool for the diagnostic histopathology and for the researchers in histology, where a slight change in the mucin pattern may help in the early diagnosis of the disease process.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

HISTOCHEMICAL CHARACTERISTICS OF MUCOSUBSTANCES IN ADENOCARCINOMA OF ENDOCERVICAL GLANDS, Dr. Ajay J.Shedge, Dr. Shedge Swapna A., Dr Mrs Padmaja A Havle, Dr.Priya Roy INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-4 | April-2019


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