Histopathological Changes in Testis of Antimony Trioxide Treated Rats

Dr. Vithal G. Patil; Dr. Y. A. Deshmukh; Dr. Atul Deshmukh

Volume : III, Issue : V, May - 2014

Histopathological Changes in Testis of Antimony Trioxide Treated Rats

Dr. Vithal G. Patil, Dr. Y. A. Deshmukh, Dr. Atul Deshmukh

Abstract :

Background : Contamination of the environment (Air, water and soil) with antimony compounds may affect human health through the continuous exposure to small doses over a long period. Therefore, the aim of the study was to evaluate the possible deleterious effects of continuous oral exposure of antimony trioxide in rat testis. Materials and Methods: Thirty three rats were randomly divided into four groups. Six rats were in control group and 9 rats in each three different test groups. Control group received no medication, test group A received 12 ppb, test group B received 500 mg/kg and test group C received 1000mg/kg of antimony trioxide daily by oral route. Result: The significant histological changes are distortion /oken epithelium, extensive edema ( vacuolization), marked decreased in number of sperms and decreased in number of layer of spermatogonia in the seminiferous tubules and marked vascular degeneration in the highest dose group as compared to the control. The present results showed that, antimony trioxide is toxic to the testis of rat.