IJSR - International Journal of Scientific Research

DR.GOGATE BAGESHRI P; Dr. SANJAY DESHMUKH

Volume : VIII, Issue : VIII, August - 2019

HISTOPATHOLOGY OF CRYPTOCOCCOSIS IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME

Dr. Gogate Bageshri P, Dr. Sanjay Deshmukh

Abstract :

BACKGROUND: Autopsy studies of AIDS form an important database for evaluation of pattern of lesions of the opportunistic infection and its association with other opportunistic infections. There is paucity of such autopsy studies in Indian literature. AIMS AND OBJECTIVES: This study was undertaken â€“To observe variations in the histomorphological patterns such as spectrum of lesions, distribution and variations in the tissue responses in Cryptococcal infection in AIDS. â€“To study different organs of the same patient and patient to patient variations. –To note other concurrent opportunistic infections with Cryptococcosis in AIDS. MATERIAL AND METHODS: The data for retrospective study was retrieved from the autopsy files of the department of pathology, B.J. Medical College, Pune between Jan 1993 to Dec 2001. Cases with documented serological diagnosis of HIV and/or patients with evidence of 1995 CDC (A) criteria for AIDS case definition, were followed and amongst these cases histopathological analysis of multiple sections from various organs were studied with H & E stain first and then special stains like mucicarmine, Gomori’s silver methanamine (GMS), Periodic Acid Schiff, Masson’s Fontana and Zeil Nelson stain were employed whenever necessary. RESULTS : Out of total 42 cases of AIDS autopsies, 12 (28.6%) cases of Cryptococci infection were documented. Of these 12 cases, 8 were complete autopsies, 3 were partial autopsies and in one case necropsy material was obtained from multiple organs. CONCLUSION: 1) The findings in this study indicated that cryptococcosis is a significant opportunistic infection in AIDS (28.57%) in India like western countries. 2) Marked variability was observed in histopathological reaction and features of Cryptococci from case to case and also in different organs of the same case. 3) Concurrent occurrence of other infections like candidiasis, PCP, Tuberculosis, Cytomegalovirus infection etc need to be ruled out even after confirmed diagnosis of Cryptococci as it has important beå in comprehensive management of AIDS patients