Volume : III, Issue : XII, December - 2014

Histopathology of Retinoblastoma: A Study of 35 Cases

Dr. Charu Meenakshi, Dr. R. N. Gosai

Abstract :

AIMS AND OBJECTIVES: To study the various demographic and histopathological features of Retinoblastoma in specimens submitted after enucleation and to compare the obtained results with relevant data from previous studies. MATERIAL AND METHODS: 35 cases with histopathological diagnosis of retinoblastoma were included in the study. Data related to age at the time of enucleation, sex, laterality, tumor size, choroidal, scleral, vitreous and optic nerve invasion, extra ocular spread, tumor differentiation and presence of necrosis and calcification was obtained. OBSERVATIONS: The median age of enucleation in patients was 22 months, (mean 30.9 months) ranging from 3 months to 107 months. 22 (62.85%) children were males with M:F ratio 1.69:1. Unilateral Retinoblastoma was found in 74.28% of cases. Necrosis (77.14%), Choroidal invasion (68.57%) and Differentiation (65.71%) were the most common Histopathological findings.Vitreous seeding was seen in 42.85% and Scleral and Optic nerve invasion in 40% each.Extra ocular spread and Optic nerve invasion to line of transection was seen in 14.28% and 8.57% respectively. CONCLUSION: Retinoblastoma is the most common intraocular tumor of childhood and it is important that attention be given to the details of the histopathological report in Retinoblastoma, particularly optic nerve invasion, extra ocular spread, scleral and choroidal invasion to determine post-enucleation therapy and prognosis.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.Charu Meenakshi, Dr. R. N. Gosai Histopathology of Retinoblastoma: a Study of 35 Cases International Journal of Scientific Research, Vol : 3, Issue : 12 December 2014

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