Hyperhomocysteinemia, Hyperglycemia and Hyperlipidemia in Atherosclerosis in Type 2 Diabetic patients

Mohammed Siddique Ahmed Khan; Mohammed Ibrahim Shaik; Shaikh Mahmood

Volume : V, Issue : X, October - 2016

Hyperhomocysteinemia, Hyperglycemia and Hyperlipidemia in Atherosclerosis in Type 2 Diabetic patients

Mohammed Siddique Ahmed Khan, Mohammed Ibrahim Shaik, Shaikh Mahmood

Abstract :

Objective: Increasing evidence has shown that atherogenesis is not only caused by hypercholesterolemia, but several other risk factors like obesity, dyslipidemia, hyperglycemia, bacterial and viral infection. Hyperhomocysteinemia also have been identified recently, all mediated through inflammation,which can lead to atherosclerosis.Several events have also been identified to be involved in the overall inflammation reaction in the blood vessel which include endothelium dysfunction, expression of adhesion molecule, recruitment of leukocytes to the injured endothelium, migration of monocytes to the arterial intima, and transformation of monocytes to macrophages, in order to facilitate the assessment of early risk for atherogenesis. We have made an effort in this study to identify soluble markers that will allow the detection of these factors and the identification of associated inflammation events. Since early risk for atherogenesis are largely preventable with dietary modification and lifestyle changes. Hyperhomocysteinemia,hyperglycemia and hyperlipidemia shown to be associated with atherosclerosis. In the present study, we aimed to evaluate the relation of plasma homocysteine levels in atherosclerotic vascular disease with hyperglycemia and hyperlipidemia in type 2 diabetic patients. Design and methods: A total number of 100 type 2 diabetic patients were included in the study of these patients, 46 had established atherosclerotic vascular disease and 54 had no evidence of atherosclerotic vascular disease. Homocysteine levels and markers of inflammation, namely C–reactive protein, fiinogen, glucose regulation and lipid parameters were studied. Results: Homocysteine levels C–reactive protein (CRP) fiinogen, glucose and lipid markers were all significantly elevated in patients with atherosclerotic vascular disease when compared with patients without vascular disease. Conclusions: Homocysteine, C–reactive protein (CRP), fiinogen, glucose and lipid levels are increased in type 2 diabetic patients with atherosclerotic vascular disease.