Volume : III, Issue : XII, December - 2014

Hyperlactatemia in critically ill newborns on presentation: Predictors, severity and outcome analysis

Surabhi Chandra

Abstract :

Aim To estimate levels of arterial lactate in critically ill newborns within 24 hours of hospitalization and to determine the severity and predictors of hyper-lactatemia and their effects on neonatal outcome. Patients and Methods Seventy-three neonates admitted to a tertiary care teaching hospital over a duration of 6 months requiring arterial blood gas analysis within the first 24 hours of hospitalization were enrolled in the study. Arterial lactate levels were estimated as a part of blood gas analysis. Hyperlactatemia was defined as lactate levels >2.5 mmol/l while severe hyperlactatemia was a value >4.0 mmol/l. Adverse outcome was defined as expiry or NICU stay of >7 days. Results Hyperlactatemia was seen in 71.2%(52/73); levels were severe in 32.9%(24/73). Significant association was seen between early (<24 hours of age) onset of symptoms (p=0.019) and hyperlactatemia. Female sex (p=0.034) and presence of hypoglycemia (p=0.052) were significantly associated with presence of severe hyperlactatemia and absence of seizures (p=0.038) with absence of the same. SNAP scores (p=0.014, 0.002), were significantly associated with presence of both hyperlactatemia and severe hyperlactatemia respectively. Absence of severe hyperlactatemia (p=0.0001) was significantly associated with good outcome. Conclusion Hyperlactatemia on admission correlates well with SNAP scores in critically ill newborns and its absence may predict good neonatal outcome.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Surabhi Chandra Hyperlactatemia in critically ill newborns on presentation: Predictors, severity and outcome analysis International Journal of Scientific Research, Vol : 3, Issue : 12 December 2014

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