Volume : VII, Issue : IX, September - 2018

HYPOGLYCEAMIC ACTIVITY OF TWO MEDICINAL CLAY; NZU AND ULO

Zaruwa, Z. Moses

Abstract :

Diabetes mellitus (DM) is a global health problem affecting million people in Africa. The consumption of medicinal clay (geophagy) by DM patients in North Eastern Nigeria, asa traditional remedyfor the ailmenthas becomevery popular. Thehypoglycaemic activity of two medicinal clay:Nzu and Ulo were evaluated. The elemental constituents of the medicinal clay were investigatedusing Atomic Absorption Spectrophotometric (AAS) analysis. Hyperglycaemia was induced in20 of 28 normoglycaemic male rats (170 – 260 g) using the Oral Glucose Tolerance Test (OGTT) protocol, and the rats were shared into seven (7) groups of four (4) rats each and treated with 100 or 200 mg kg–1 of Nzu or Ulo, respectively. Elemental analysis of both claysamples, showed the presence of Zn, Pb, Mg and Ni aboveWHOrecommended levelsper day.The mean blood glucose level of the hyperglycaemic treated rats in group III, IV, V, VI and VII after administration of the medicinal clay (Nzu and Ulo) was compared with values in the control groups (I and II) and the Glibenclamide treated group. Significant (p Ë‚0.05) reduction in the blood glucose concentrations after 1st, 2nd, 3rd hours were observed between the hyperglycaemic treated and untreated rats. The control drug Glibenclamide (600 µg/kg) showed much lover blood glucose concentration at the 3rdhour above the medicinal clay.It was concluded therefore, that the possible reason for the observed hypoglycaemia, could be due to delayed digestion and assimilation of food, within the gut of the rat or slowed to enable a gradual absorption and catalysis of the glucose within the cells.The consumption of 100 and 200 mg/kg b.wt. Nzu and Ulo reduced blood glucose levels in hyperglycaemic rats and it justified in the management of diabetes mellitus.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Zaruwa, Z. Moses, HYPOGLYCEAMIC ACTIVITY OF TWO MEDICINAL CLAY; NZU AND ULO, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-9 | September-2018


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