Identification and evaluating the role of  metal ion transporters in Dienococcus  radiodurans using insilico tools

Dr. P.Kiranmayi; Satabdi Rautray; Dr. K.Vijaya Rachel; Kunal Zaveri

Volume : II, Issue : VIII, August - 2013

Identification and evaluating the role of metal ion transporters in Dienococcus radiodurans using insilico tools

Dr. P. Kiranmayi, Satabdi Rautray, Dr. K. Vijaya Rachel, Kunal Zaveri

Abstract :

Most radiation resistant bacterium Dienococcus radiodurans accomplishes its ability to resist the toxic effects of metals by transporting and transforming them to less toxic metal ions utilizing metal ion transporters. Identification and understanding the role of metal ion transporters in D. radiodurans helps us to know their mechanism of maintaining ion level concentrations in adverse conditions and their role in bioremediation process. In the present study, a complete catalogue of 33 metal ion transporters was identified. Of these 33 metal transporters, the interactions and interacting partners for manganese, iron and mercury transporters were analyzed using STRING, as these metal ions are the remnants in the spent decontaminating solutions released from many industries and nuclear power plants which are hazardous. The interaction studies show that the three metal ion transporters are interacting with each other which might play a crucial role in imparting radiation resistance to this organism.