Volume : II, Issue : VI, June - 2013

Imidacloprid–Induced Nephrotoxicity in Male Rats

S. Soujanya, M. Lakshman

Abstract :

Protective role of vitamin C was assessed against imidacloprid-induced nephrotoxicity. Forty eight male Sprague dawley rats were divided into four groups of 12 animals in each. Group 1 served as control, while groups 2 and 4 were administered with imidacloprid (80 mg/kg b.wt) daily by oral gavage for 28 days. In addition to imidacloprid, group 4 also received vitamin C @ 10 mg/kg/oral daily for 28 days. Group 3 was maintained as vitamin C control (dose as above). At the end of 14th day, six rats from each group and the remaining at the end of 28th day were sacrificed. Blood samples were collected before sacrifice for sero-biochemical analysis. In group 2, a significant (P<0.05) increase in serum creatinine and decrease in GSH concentration in kidney was observed. In group 2, histological examination revealed pathologically significant changes. Co-treatment with vitamin C significantly (p<0.05) reversed the imidacloprid-induced nephrotoxicity

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

S. Soujanya, M. Lakshman Imidacloprid-Induced Nephrotoxicity in Male Rats International Journal of Scientific Research, Vol : 2, Issue : 6 June 2013

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