IMMUNOHISTOCHEMICAL PHOSPHOTENSIN TUMOUR SUPPRESSOR GENE(PTEN) STAINING IN ENDOMETRIAL HYPERPLASIAS IN COMPARISON TO ENDOMETRIAL CARCINOMASA 4 YEAR STUDY

Dr.Devi.J; Dr.R.Sathyalakshmi; Dr.S.Ashok

Volume : VI, Issue : V, May - 2017

IMMUNOHISTOCHEMICAL PHOSPHOTENSIN TUMOUR SUPPRESSOR GENE(PTEN) STAINING IN ENDOMETRIAL HYPERPLASIAS IN COMPARISON TO ENDOMETRIAL CARCINOMASA 4 YEAR STUDY

Dr. Devi. J, Dr. R. Sathyalakshmi, Dr. S. Ashok

Abstract :

Endometrial Hyperplasia is a precancerous lesion that can cause Endometrial carcinoma.Endometrial carcinoma is a common neoplasm of the female genital tract that is associated with a considerable degree of morbidity.The pathologist plays a vital role in identifying the subset or factors in endometrial hyperplasia that can lead to carcinoma.PTEN is one such factor that is important.AIM:Submission of Endometrial hyperplasia cases to determine the different patterns of PTEN expression by studying the PTEN intensity,% positivity,differences in the expression patterns of glandular and stromal staining and the variability in the number and distribution of PTEN null glands in various types of hyperplasias.To study the pattern of PTEN staining in endometrial carcinomas and comp� it with that of endometrial hyperplasia.SETTINGS AND DESIGNS:The study was done in the biopsy samples received in the Department of Pathology, Stanley Medical College and Vellore Medical College from January 2012–December 2015.MATERIALS AND METHODS:A retrospective and prospective study was done over 4 years in our study including a total of 132 cases which included 100 cases of endometrial hyperplasias and 14 cases of endometrial carcinomas.PTEN staining pattern was evaluated.Statistical analysis of analysing the P value was carried out by using Fischer�s Exact Test.RESULTS:Endometrial hyperplasia with atypia showed a reduction in the number of strongly positive PTEN glands and increase in null gland clusters.CONCLUSION:PTEN expression in Endometrial hyperplasia is an early warning sign for increased cancer risk and potential target for preventive treatment.