IJSR - International Journal of Scientific Research

M. SIVA SANKAR; K. SUJATHA; P. NEERAJA

Volume : III, Issue : I, January - 2014

Impact of Sodium Selenite on Antioxidative Metabolism in Kidney Tissue of Albino Rat Under Ammonia Stress

M. Siva Sankar, K. Sujatha, P. Neeraja

Abstract :

The present study aims to examine whether selenium alleviates ammonia stress conditions. The LD50 of Ammonium Sulphate and Sodium Selenite was determined, after toxicity testing evaluation. It is 62.5 mg/kg body weight for ammonium sulphate and 1.5mg/kg body weight for sodium selenite. The selected sub lethal concentrations of ammonium sulphate and sodium selenite are 12.5 mg/kg body weight and 0.3 mg/kg body weight respectively. These are administered through intraperitonial method to rats for one week. After one week treatment, antioxidative enzymes like Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione reductase (GR) activities were estimated in Kidney tissue of albino rats by using standard methods. The impact of sodium selenite in rat under ammonia stress is discussed.