Volume : III, Issue : VIII, August - 2014

In Silico Molecular Interaction Analysis Of Type I Collagen Telopeptides With Cyclodextrins

Lavanya Gunamalai, C. Jaynthy

Abstract :

Type I Collagen is the extracellular matrix protein of skin, tendon, bone etc. The proteomic feature of the collagen is of triple helical form, but the ends are capped by short peptide extensions, called Telopeptides, which are non-helical in nature. Normally telopeptides of collagen denatures at 35°C, but in the presence of α, β and γ cyclodextrins the denaturation can be prevented until 40°C. Increasing concentration of cyclodextrin resulted in aggregation of the protein. Further, cyclodextrin imparts high level of thermal stability to collagen with shrinkage temperature of collagen. It was known that the hydrophobic amino acids play an important role in the fiil formation of collagen. . In this current study , Type I Collagen telopeptide chains were modeled using modeler software also docked with α, β and γ cyclodextrins.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Lavanya Gunamalai, C.Jaynthy In Silico Molecular Interaction Analysis Of Type I Collagen Telopeptides With Cyclodextrins International Journal of Scientific Research, Vol : 3, Issue : 8 August 2014

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