In Vitro Analysis on The Cytotoxicity of Super paramagnetic Iron Oxide Nano particle (SPION) Mediated Anticancer Drug Delivery System.

Naheef; K; Vysakh Mohan; Sivanarayanan  TB

Volume : III, Issue : VIII, August - 2014

In Vitro Analysis on The Cytotoxicity of Super paramagnetic Iron Oxide Nano particle (SPION) Mediated Anticancer Drug Delivery System.

Naheef, K, Vysakh Mohan, Sivanarayanan Tb

Abstract :

In this study, we present in vitro cytotoxicity of bare and surface modified iron oxide (Fe3O4) nanoparticles) using live cell assays, LDH, and MTT assays with variation of the concentration of nanoparticles and incubation time. The surface of nanoparticles is modified with 3-aminopropyl triethoxy silane to enhance the biocompatibility. While the cytotoxic effect was negligible for 24 h incubation even at highest concentration of 100 μg/ml. Bare nanoparticle represented higher level of toxicity than those of silanised nanoparticles. Current results confirmed the predictions and demonstrated that Magnetic nanoparticle (MNP)-silane system functionalised with silane has potential as new targeting strategy in cancer therapy