In Vitro Anticancer and Biological Activity Studies for New Synthesized Transition Metal Ternary Complexes

Eman H. Ismail; Amal I. Abdel–Mageed; Heba Mohamed; Mostafa M. H. Khalil

Volume : IV, Issue : VII, July - 2015

In Vitro Anticancer and Biological Activity Studies for New Synthesized Transition Metal Ternary Complexes

Eman H. Ismail, Amal I. Abdel Ndash Mageed, Heba Mohamed, Mostafa M. H. Khalil

Abstract :

<p>&nbsp;Ternary complexes of Co (II), Ni (II), Cu (II) and Zn (II) with glutamic acid (glu) as a primary ligand and leucine (leu) or valine (val) as secondary ligand were prepared in slightly acidic medium. The structures of the complexes were elucidated using elemental, IR, mass spectra, magnetic moment, UV&ndash;Vis spectrophotometer and thermal analyses. The ternary complexes were isolated in 1:1:1 molar ratio and the molecular structures were found to be M(glutamic)(leucine)(H2O)2].H2O and [M(glutamic) (valine)(H2O)2].H2O, where M = Co(II), Ni(II). Thermogravimetric analysis confirmed that two water molecules coordinated to the central metal atom and one crystalline water molecule. UV&ndash;Vis spectra showed that the complexes have octahedral symmetry. On the other side, ternary copper complexes with molecular formula [Cu(glu)(leu)] and [Cu(glu)(val)] where the two amino acids coordinated using oxygen and nitrogen forming distorted square planar structure as further supported by electron spin resonance ESR spectra. The ternary zinc complexes showed that the glutamic acid acted as tridentate ligand while leucine or valine acted as monodentate ligands. Moreover, the ligands and their metal complexes were screened against bacteria and fungi using the inhibitory zone diameter. Furthermore, the complexes were tested their cytotoxicity effects against three types of human cancer cell lines hepatocellular carcinoma (HePG2), human colonic carcinoma (HCT) and east cancer cell lines (MCF&ndash;7).</p>