In vitro evaluation of anticancer and antimicrobial activity of selected medicinal plants for breast cancer

Aashrith Jayanth; Neeta Shivakumar; Akshay Kumar R

Volume : IV, Issue : IV, April - 2015

In vitro evaluation of anticancer and antimicrobial activity of selected medicinal plants for breast cancer

Aashrith Jayanth, Neeta Shivakumar, Akshay Kumar R

Abstract :

The use of natural substances to inhibit carcinogenesis is a rapidly evolving aspect of cancer research. In present

investigation the methanolic extract of Taxus baccata, lallemantia royleana and Podophyllum hexandrum were

evaluated for their in vitro anticancer and antimicrobial activity. The results obtained indicates that Podophyllum hexandrum possess a

potential inhibiting activity of IC50 116�g/mL towards MCF-7. The selected plant samples were also assessed for their antimicrobial activity

against Bacillus subtilis and Aspergillus niger and the minimum inhibitory concentrations (MICs) were determined using micro dilution assay. In general, it was observed that the extract of Podophyllum hexandrum was found to be more effective against selected microbial strains.

The results of the present findings may be useful for the discovery of novel anticancer and antimicrobial agents from the plant origin.