INCIDENCE, PATTERN AND CHARACTERIZATION OF IMMUNE THROMBOCYTOPENIC PURPURA

DR.HOOGAR M.B.; DR. PUJA IYENGAR; DR. UJWALA MAHESHWARI; DR. ATUL JAIN

Volume : V, Issue : VI, June - 2016

INCIDENCE, PATTERN AND CHARACTERIZATION OF IMMUNE THROMBOCYTOPENIC PURPURA

Dr. Hoogar M. B. , Dr. Puja Iyengar, Dr. Ujwala Maheshwari, Dr. Atul Jain

Abstract :

 INTRODUCTION: Immune thrombocytopenic purpura (ITP) is a relatively uncommon disorder of acquired immune mechanism. Due to lack of adequate relevant data in India pertaining to incidence of immune thrombocytopenic purpura, designing of suitable clinical models and health resource allocation has become a little abstract and demanding. Knowledge of epidemiology and pattern of immune thrombocytopenia purpura is essential for devising new clinical trials and management of the condition. OBJECTIVES: The objective of the present study is to determine the incidence, pattern and characterization by analyzing the data of routine haematological investigations in haematology laboratory of a tertiary care hospital. METHODS: The present study is to determine the incidence and pattern of immune thrombocytopenic purpura by analyzing data of routine haematological investigations on the blood samples received in haematology laboratory of a tertiary care hospital located in peripheral area of Navi Mumbai with a mixed semi–urban and rural populations of diverse ethnic and socio–economic backgrounds. RESULTS: In the present study, a total of 206 cases of immune thrombocytopenic purpura (ITP) are diagnosed by analyzing the data of haematological investigations of blood samples of 17,620 patients. Out of 206 (1.16%) cases of immune thrombocytopenic purpura, 138 (67%) cases are males and 68 (33%) cases are females. In the study, 24 (11.6%) cases are children, while 182 (88.3%) of cases occurred in patients over 12 years of age. 13 (6.3%) cases are known cases of ITP, while 193 (93.7%) cases are associated with other clinical conditions. In the current study, ITP is associated with 71 (34.4%) cases of Malaria and 35 (17%) cases of Dengue. CONCLUSION: The present study shows an overall increased incidence of ITP based on analysis of database of routine haematological investigations carried out on blood samples of patients received in haematology laboratory of a tertiary care hospital. The study shows an increased incidence of ITP in adults than in children and also an increased incidence of ITP in males than in females. The overall increased incidence of ITP could be due to increased incidence causes of ITP such as co–existence of Malaria, which forms one–third of all the cases of ITP in the present study, Dengue and other clinical conditions such as alcoholic liver disease, malignancies and other conditions such as bacterial and viral infections and non–infectious conditions and their drug therapy that could collectively have led to secondary ITP.