INTRAVENOUS DEXMEDETOMIDINE AS AN ADJUNCT TO ANAESTHETIC INDUCTION TO ATTENUATE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dr. Savita Meena; Dr. Kavita Jain; Dr. Neena Jain

Volume : VII, Issue : IV, April - 2018

INTRAVENOUS DEXMEDETOMIDINE AS AN ADJUNCT TO ANAESTHETIC INDUCTION TO ATTENUATE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dr. Savita Meena, Dr. Kavita Jain, Dr. Neena Jain

Abstract :

Background: The purpose of this study was to evaluate the effect of a single pre–induction intravenous dose of dexmedetomidine 1mcgkg on cardiovascular response resulting from laryngoscopy and endotracheal intubation.

Methods: Sixty patients ASA grade I and II scheduled for elective surgery under general anaesthesia were randomized into two groups(dexmedetomidine group{B} and placebo group{A},n=30 in each group).Haemodynamic parameters and adverse effects were recorded before intubation and during intubation.

Result: In the present study,two groups were comparable. Mean(�SD)heart rate(beats/min) increased from the basal value of 84.20�13.16 to 107.07�11.47 (21.4%) during laryngoscopy and endotracheal intubation in group A whereas in group B it increased from basal value of 82.97�7.69 to 84.13�7.33(2.38%) (p<0.01).Mean (�SD) SBP increased from basal value of 125.40�10.97 to 143.61�11.59 mm Hg(12.58%) in group A whereas in groupB it increased from 126.93�7.63 to 128.60�9.62 mm Hg(1.56%) (p<0.01).Mean DBP increased from basal value of 80.90�5.58 to 92.57�5.89 (13.04%) in group A whereas in groupB it increased from basal value of 81.63�4.19 to 83.00�6.49 (2.4%) (p<0.01). Mean arterial pressure increased from basal value of 95.71�7.02 to 109.57�7.31 (12.8%) in groupA whereas in groupB it increased from96.74�4.87 to 98.17�7.01(2.04%) (p<0.01). Thus the increase in heart rate, SBP, DBP and MAP were significantly lower in Dexmedetomidine group (p<0.01).

Conclusion: Preoperative administration of a single IV dose (1�g/kg) of dexmedetomidine can be used as an adjuvant to anesthetic induction to attenuate haemodynamic responses during laryngosopy and endotracheal intubation.