Volume : V, Issue : VI, June - 2016

Intravenous labetalol in the management of severe pregnancyinduced hypertension

Archana Bharti, Ajay Chhikara

Abstract :

 Objective: To study the maternal and fetal outcome in patients with severe pregnancy–induced hypertension treated with intra–venous labetalol. Methods: A prospective hospital based study was conducted in the Department of Obstetrics & Gynecology, Maharaja Agrasen Medical College, Agroha, Hisar from January 2013 to August 2013.Twenty five patients with severe pregnancy induced hypertension received intravenous labetalol in sequentially escalating dosages every 15 minutes (10mg, 20 mg, 40 mg, 80mg and maximum 220 mg). Target was to achieve systolic blood pressure of <155 mm Hg and diastolic blood pressure of <105 mm Hg. Age, gravid Status, gestational Age, efficacy of the drug to achieve target blood pressure, time taken to Control Blood Pressure, drug dosage required, systolic and diastolic blood pressures during first hour, side effects, maternal and Perinatal outcomes were studied. Results: The pretreatment mean systolic and diastolic blood pressure were 185.4 ± 13.5 mmHg and 120.3 ± 4.6 mm Hg respectively. Target blood pressure was achieved in 19(76%) patients. The mean time taken to control blood pressure in the study group was 57.63± 14.37 minutes. The mean number of drug dosages required were 3.84±0.95. The mean apgar score at 5 minute was 8.29±1.3 and the side effects were tolerable. Conclusion: Intra–venous labetalol is an effective first line anti–hypertensive drug for acute control of blood pressure in the management of severe pregnancy induced hypertension. The maternal and fetal outcome is good with minimal side effects.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Archana Bharti, Ajay Chhikara Intravenous labetalol in the management of severe pregnancyinduced hypertension International Journal of Scientific Research,Vol : 5, Issue : 6 JUNE 2016

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