Volume : IV, Issue : IX, September - 2015

Iron status of thalassemic Children in South Rajasthan

Madhu Choudhary, Dr. V. D. Bohra

Abstract :

Background–Thalassemias are a group of inherited autosomal recessive disorders caused by defects in the synthesis of one or more of the hemoglobin chains, cause hemolysis and impair erythropoiesis. . Repetitive blood transfusion leads to iron overload which adversely affect the function of liver, heart and endocrine glands. Objective– The aim of this study was to evaluate the status of iron in β–thalassemia major children with means of ferritin, transferrin, TIBC and % TS. Methods–The analyzed group consisted 50 subjects and 50 controls further divided in two age groups i.e. I and II. Ferritin was measured by ferrozine method. Results–Thalassemic subjects have significantly higher iron, ferritin, % TS and reduced levels of TIBC and transferrin. Conclusions– Evaluation of ferritin in thalassemic children help in monitoring, the level of iron obtained by repetitive blood transfusions and there for the damage of a number of organs. In spite of chelation therapy ferritin was found to be elevated several folds in subjects.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Madhu Choudhary, Dr. V.D. Bohra Iron status of thalassemic Children in South Rajasthan International Journal of Scientific Research, Vol : 4, Issue : 9 September 2015

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