Is locally advanced Cancer cervix associated with Hypoalbuminemia and increased Granulocyte and Lymphocyte ratio?

Sandeep Kumar; Noopur Nelson; Manisha Roy; Govardhan; Khaleel; Pallavi; Ramesh

Volume : VIII, Issue : III, March - 2019

Is locally advanced Cancer cervix associated with Hypoalbuminemia and increased Granulocyte and Lymphocyte ratio?

Sandeep Kumar, Noopur Nelson, Manisha Roy, Govardhan, Khaleel, Pallavi, Ramesh

Abstract :

Background:With a background of difference in the roles of neutrophils in cancer patients compared to those with no malignancy, notedhigher incidence of hypoalbuminemia in critically ill patients with cancer admitted to ICU and paucity of literature establishing their association, in the current study setting the study was conducted. Objective:To determine the association of hypoalbuminemia and increase Granulocyte and Lymphocyte ratio (GLR) with locally advanced cancer cervix. Materials and Methods:Record based analysis was conducted among 96 locally advanced cancer cervix patients during the study period of 3 years at Kidwai Memorial Institute of Oncology, Bangalore. Granulocyte lymphocyte ratio, hypoalbuminemia and other required data were collected. Correlation of albumin levels and GLR with stages of cancer cervix was determined using Spearman�s correlation coefficient (r). Logistic regression was undertaken to assess the various factors associated with hypoalbuminemia and GLR. A P value < 0.05 was considered statistically significant. Results: The mean age of the study participants was 50 years and majority (57.2%) were in III B stage. With the progression of stages, GLR increased and albumin decreased significantly (P<0.05). Though hypoalbuminemia and raised GLR were not significantly associated and were not independent markers for locally advanced carcinoma cervix of stage ≥ III B, the risk of hypoalbuminemia and raised GLR were 3 times and 1 time higher among those with advanced stage of ≥ III B compared to lower stages of carcinoma cervix respectively (P>0.05). Conclusion: Hypoalbuminemia and raised GLR were not significantly associated however the proportions are higher among those with advanced stage of cancer cervix. Their roles as independent markers could better be established in higher sample sizes and retrospective or prospective study designs.