IJSR - International Journal of Scientific Research

Srinu Meesala; Chandraiah Godugu; Milind G. Watve

Volume : VI, Issue : I, January - 2017

Isolation and Xray crystal structure of 1,3,9 trimethyl purine derivative having cytotoxic activities from marine sponge Amphimedon viridis (Duchassaing & Michelotti,1864)

Srinu Meesala, Chandraiah Godugu, Milind G. Watve

Abstract :

A new purine derivative 1,3,9 trimethyl uric acid (1) was isolated from the marine sponge Amphimedon viridis and structure were confirmed by X–ray crystallography data. Compound 1 exhibited in vitro cytotoxic activity against east cancer (MCF–7), human neuroblastoma (SHSY5Y), human non–small cell lung cancer (A549) and human liver cancer (HEPG2) with IC₅₀ value in the range of 1–3 µM and also showed promising anti–inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100–1000 nM.