Ki67 expression in invasive ductal and invasive lobular carcinomas of breast

Volume : VI, Issue : VIII, August - 2017

Snigdha Sinha, Dr Aruthra

Aim: To study the expression of Ki–67 in invasive ductal and invasive lobular carcinomas

of east and analyze its utility in predicting the response to chemotherapy and as a

prognostic marker. Materials and methods: A total of fifty east carcinoma specimen

were investigated comprising of forty invasive ductal carcinomas and ten invasive lobular

carcinomas. Haematoxylin and Eosin slides of all the tissues were evaluated.The formalin

fixed, paraffin embedded blocks were sliced in 3–4 �m thickness for IHC. The Avidin Biotin

complex (ABC) detection system was used. Immunoreactivity was regarded as positive when

own staining was localized to the nucleus of the tumor cells. Results: Ki–67 expression

was observed in invasive ductal carcinoma(IDC) and invasive lobular carcinoma(ILC) and

graded as low, intermediate and high.

Conclusion

Out of the 40 cases of invasive ductal carcinoma Ki67 was found to have high expression in

20 (50%) patients, intermediate expression in 13(32.5%) patients and low in 7(17.5%)

patients. Out of the 10 cases of invasive lobular carcinoma Ki–67 was found to have high

expression in 5(50%) patients intermediate expression in 3(30%) patients and low expression

in 2(20%) patients.