Volume : VIII, Issue : III, March - 2019

LIFE EVENTS INFLUENCE THE DEVELOPMENT OF RHEUMATIC DISEASES: A CASE CONTROL STUDY

Apurva Khare, D P Singh, Roopesh Jain

Abstract :

Stress and stressful life events aggravate rheumatic disease development. With pre–existing susceptibility to genetic background, this case–control study explores the relationship amongst life events, hassling personality and coping strategy. This is case control study in which 20 male who fulfill New york criteria1. Twenty male Rheumatic disease patients, mean age was 24.5 (21–30) yrs, with a duration of disease 3.25 (0.5–5)cyrs with ESR 43 (28–67) and CRP 9.25 93–21) ng per dl. All the patients were on NSAID and disease modifying drugs at the point of screening. Five had received Infleximab and methotrexate and all remaining were on methotrexate and Salazopyrine. AS, a chronic inflammatory rheumatic disorder predominantly affecting the spine, has a substantial impact on the physical and emotional functioning and the quality of life. Literature evidence indicates the causal relationship between stress and onset of autoimmune diseases. Studies have concluded that infection and work stressors along with genetic predisposition may serve as potential triggers of rheumatic disease onset. The current study results also states the influence of stressful and traumatic life events in the development of rheumatic disease, especially in susceptible individuals. The life events and their impact by the nature of the personality is significantly different in patients with rheumatic diseases compared to the control group. Hence we conclude life stresses seems to be playing a critical role in the development the disease

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

LIFE EVENTS INFLUENCE THE DEVELOPMENT OF RHEUMATIC DISEASES: A CASE CONTROL STUDY, Apurva Khare, D P Singh, Roopesh Jain INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-3 | March-2019

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