Volume : VI, Issue : XII, December - 2017

LONG TERM TOXICITY STUDY OF CHANDRAKANTHI CHOORANAM

B. Akila, K. Manickavasakam, T. Kavitha

Abstract :

 WHO guidelines intends to specify the standard system in toxicological studies (non–clinical) associated in assessing the herbal medicine safety.In Siddha science, 96 thathuvam (principles) deals with the basic components of human body which include intellectual, physiological, physical and psychological components of the individual. Siddha herbo mineral formulation, Chandrakanthi Chooranam (CKC) is a sastric preparation indicated for oligozoospermia; poly urea; vaginal disease; veneral disease and biliousness.Acute oral toxicity study of CKC revealed that it is well tolerated up to 10.8gm/kg b.wt [10 times the therapeutic dose(1.08 gms/day)] in wistar rats. The present long term toxicity study is the further extension of the acute toxicity study and to validate the safety profile of CKC in wistar rats and was carried out following the World Health Organization (WHO) guidelines 2000. Three dose levels of 1.08gm/kg b.wt (therapeutic dose); 3.24g/kg b.wt (3 x Therapeutic dose) and 5.4gm/kg b.wt. (5 x Therapeutic dose) were administered to rats for duration of 90 days. Long term toxicity study was assessed by estimating physiological, biochemical, hematological and histopathological effects of CKC on rats.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

B.Akila, K.Manickavasakam, T.Kavitha, LONG TERM TOXICITY STUDY OF CHANDRAKANTHI CHOORANAM, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-12 | December-2017

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