IJSR - International Journal of Scientific Research

Syed Hassan Mehdi; Ayesha Qamar; Md.Zafaryab; Sana Nafees; M.Moshahid Alam Rizvi

Volume : VI, Issue : XII, December - 2017

Malathion–Induced cell injury and cell death in the Nervous System via Oxidative–Stress–Induced Cytotoxicity in Drosophila melanogaster

Syed Hassan Mehdi, Ayesha Qamar, Md. Zafaryab, Sana Nafees, M. Moshahid Alam Rizvi

Abstract :

In the present study we have investigated the effect of Malathion on the nervous system of Drosophila melanogaster (DM). Our study evaluated the effect of sub chronic exposure of Malathion on the neuropathology, genotoxicity and antioxidant activity. We have also studied the effect of Malathion by validating its cytotoxic effects. Our study shows dose dependent Malathion induced neuropathology in the ain tissue of D. melanogaster as evidenced by silver nitrate staining, transmission electron microscopy and decreased super oxidative dismutase specific activity induced Malathion treated D. melanogaster. We have also employed its significant association with oxidative DNA damage as observed by alkaline comet assay. Additionally we have also evaluated the cytotoxic damage induced by Malathion in Dmel–2 cells suggesting the loss of neuronal cells viability. Thus our findings demonstrated that Malathion induced toxicity resulted in neuroanatomical changes with neurotoxic damages to the nervous system.