MALIGNANT NODULAR HIDRADENOMA: A Report of Two Cases and Review of the Literature

Ipsita Pradhan; Anupa Toppo; Alaka Sahoo; Kailash ch. Agrawal

Volume : VIII, Issue : IV, April - 2019

MALIGNANT NODULAR HIDRADENOMA: A Report of Two Cases and Review of the Literature

Ipsita Pradhan, Anupa Toppo, Alaka Sahoo, Kailash Ch. Agrawal

Abstract :

INTRODUCTION: Malignant nodular hidradenoma is a rare tumor of sweat gland.It was first reported as clear cell eccrine carcinoma by Keasbey and Hadley in 1954.The biological behaviour of the tumor is aggressive and are highly prone for recurrence. CASE REPORT: We report two cases of malignant hidradenoma,one presented with a scalp swelling and other chest wall swelling.FNAC and biopsy was done in both the cases.The histomorphology was confirmed by running a panel of immunohistochemical marker and the diagnosis of malignant hidradenoma was ascertained. DISCUSSION: Sweat gland tumors are mostly benign.Malignant nodular hidradenoma according to WHO classification comes under malignant tumor of skin appendages with apocrine and eccrine differentiation.MNH displays an infiltrative or invasive pattern,atypical mitosis,necrosis & angiolymphatic invasion which favours its malignant nature.It can take its origin from a pre–existing hidradenoma or can arise denovo.The tumor is extremely rare with less than 50 cases ever reported in literature.The prefered management is early wide excision with atleast 2cm clear margin for both primary disease and local recurrences.