Volume : VII, Issue : VIII, August - 2018

Management Of Acute Hypertension In Pregnancy- Labetalol V/s Hydrazine

Dr. Priyanka Singh, Dr. Nidhi Garg, Prof. Noor Afshan Sabzposh

Abstract :

 Objective: To assess the safety, potency and effectiveness of intravenous hydralazine and labetalol for acutely lowering severe blood pressure in

pregnancy and to compare maternal and perinatal outcome.
Method: In a prospective randomized study, women attending labor room and antenatal out patient department of Jawaharlal Nehru Medical
College and Hospital during January 2014 to October 2015 were enrolled. The inclusion criteria were women with ≥24 weeks gestational age,
blood pressure ≥160/110 mmHg with or without proteinuria and no concurrent anti–hypertensive therapy. Patients were randomized in two groups
using simple randomized sampling, either receiving intravenous labetalol (Group A) or intravenous hydralazine (Group B) according to predecided
protocol. The primary outcome was defined as lowering of blood pressure ≤ 160/110 mmHg taking into consideration the number of doses
and time duration required to lower the blood pressure.
Result: Analysis elucidated a significant fall in systolic and diastolic blood pressure by both drugs (p value<0.05). The fall in both systolic and
diastolic blood pressure was insignificant when compared between the two groups after 20 minutes. When measured at 40, 60 and 80 minutes the
fall in systolic blood pressure was more significant in hydralazine group as compared to labetalol group. The fall in diastolic blood pressure remains
almost equivalent at all intervals between both the groups
Conclusion: For women with severe blood pressure, both labetalol and hydralazine are equally effective in pregnancy.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Priyanka Singh, Dr. Nidhi Garg, Prof. Noor Afshan Sabzposh, Management Of Acute Hypertension In Pregnancy– Labetalol V/s Hydrazine, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-8 | August-2018


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