Measurement of eCO as a biomarker of oxidative stress in Obstructive Pulmonary Disease

Mohammad Shameem; Nazish Fatima; Nabeela; Shahnawaz Mohd; Zia-ul-Hasan

Volume : VI, Issue : XII, December - 2017

Measurement of eCO as a biomarker of oxidative stress in Obstructive Pulmonary Disease

Mohammad Shameem, Nazish Fatima, Nabeela, Shahnawaz Mohd, Zia Ul Hasan

Abstract :

COPD is a disease of increasing public health importance around the world. COPD has become a major but neglected public health problem and is leading cause of death and disability worldwide with a growing population prevalence of 4–10% based on spirometry test. The aim of our study to measure the level of exhaled CO as a non–invasive biomarker in COPD.

The present study was conducted at department of TB & Respiratory Diseases, JN Medical College, AMU, Aligarh. The clinical severity of asthma and COPD was determined using the criteria defined in the GINA and GOLD guidelines. Spirometry was used to confirm the presence of airway obstruction.

In this study we found that on applying One Way ANNOVA difference in the mean eCO level was found to be significant (p<0.05).

It has been shown that exhaled CO levels increases during an asthma and COPD exacerbation. Therefore, measurement of exhaled CO may be a simple method of detecting and assessing airway inflammation in asthma and COPD.