Metabolic Syndrome in Stable COPD Patients amongst North Indian population: A case control study

Akashdeep Singh; Manikant Singla; RK Soni

Volume : VII, Issue : II, February - 2018

Metabolic Syndrome in Stable COPD Patients amongst North Indian population: A case control study

Akashdeep Singh, Manikant Singla, Rk Soni

Abstract :

Background: Metabolic syndrome predisposes the affected individual to cardiovascular disease and type 2 diabetes. The prevalence of metabolic syndrome in chronic obstructive airway disease (COPD) varies with ethnicity.

Aims: The aim of the present study was to investigate the frequency of metabolic syndrome in stable COPD patients compared to age and sex–matched controls from North India and to find any association of it with severity of COPD.

Settings and Design: A prospective analytical study conducted in the chest clinic of a tertiary care teaching hospital.

Material and methods: The study comprised of two groups involving 134 subjects including 67 stable COPD patients and an equal number of healthy controls for the presence of metabolic syndrome. The two groups were age and sex matched. Anthropometric measurements were taken. Fasting blood sample was collected to measure the blood glucose (FBG), triglyceride (TG), and high–density lipoprotein (HDL). The presence of metabolic syndrome was assessed using the modified NCEP ATP III criteria.

Results: The occurrence of metabolic syndrome was found to be significantly higher in the COPD patients (49.3%) than in control group (29.9%). Components of metabolic syndrome which were significantly more prevalent in the COPD patients included raised serum triglyceride, low HDL–C and hypertension. Although waist circumference, fasting glucose were more prevalent in the COPD patients but the difference was not statistically significant. The prevalence of metabolic syndrome was significantly more in obese COPD patients with GOLD stage II.

Conclusion: Metabolic syndrome is common among stable COPD patients. It is more prevalent in GOLD stage II patients who have a BMI> 25 kg/m².