Volume : III, Issue : IX, September - 2014

Microsatellite Chromosomal Instability in Bladder Cancer Patients Infected with Hepatitis C Virus

Kamel Zaki Hemmaid, Amira Awadalla, Hassan Aboelenin, Abdelaziz Hussein, Essamelsawy, Mai B Mohammed, Abd El Rahman, Nabawy Zekri

Abstract :

The objective of this study was to investigate the impact of HCV infection on MSI in cancer bladder. Tissue samples from 100 (50 HCV infected and 50 non–HCV infected) patients (aged 17– 89 years). Surgical specimens were obtained by radical cystectomy of bladder tumors. The frequency of MSI +LOH in D9S162 locus (40%) was higher than that of D9S171 locus (34%). Moreover, there was positive correlation between HCV infection and MSI in D9S171 and D9S162 loci 9. LOH and MSI of D9S171 and D9S162 loci were more frequent in cancer bladder tissues than normal tissues as well as the frequency was higher in HCV infected patients.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Kamel Zaki Hemmaid, Amira Awadalla, Hassan Aboelenin, Abdelaziz Hussein, EssamElsawy, Mai B Mohammed, Abd El-Rahman, Nabawy Zekri Microsatellite Chromosomal Instability in Bladder Cancer Patients Infected with Hepatitis C Virus International Journal of Scientific Research, Vol : 3, Issue : 9 September 2014

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