Volume : IX, Issue : V, May - 2020

Morphometric Study Of Endometrial Glandular Lesions In The Perimenopausal And Postmenopausal Age Group With Special Reference To Proliferative Activity

Dr. Neeraj Kumar, Dr. Lalita Khess, Dr. Jalandhar Mehra

Abstract :

Morphology is the keystone in the evaluation of Endometrial Glandular Lesions, but morphometric evaluation and immunohistochemistry can also be helpful in establishing the correct diagnosis. Morphometric measurements using variables like mean nuclear diameter, mean cytoplasmic diameter, mean nuclear area, N/C ratio, nuclear perimeter help in classifying different glandular lesions of endometrium, especially in dilemma in concluding a lesion benign, premalignant or malignant. The present study is to see the frequency of glandular lesions of endometrium with focus on the avoidance of common diagnostic pitfalls from the correlation between histomorphological, morphometrical studies and immunohistochemical marker studies. The present study was done at the Department of Pathology, Rajendra Institute of medical sciences, Ranchi between July,2018 to September 2019. Highest number of cases (35%) belonged to hormone induced changes (both exogenous and endogenous)of endometrium in this study. Endometrioid adenocarcinoma constituted the major percentage of cases (82.14%) among carcinoma. Mean nuclear diameter >7.339µm indicating probability of malignancy with sensitivity 85.71 and specificity 89.47 was found. We concluded that morphometric study can be used to differentiate various benign, borderline endometrial glandular lesions from malignant endometrial glandular lesions in perimenopausal and postmenopausal age group.

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

MORPHOMETRIC STUDY OF ENDOMETRIAL GLANDULAR LESIONS IN THE PERIMENOPAUSAL AND POSTMENOPAUSAL AGE GROUP WITH SPECIAL REFERENCE TO PROLIFERATIVE ACTIVITY, Dr. Neeraj Kumar, Dr. Lalita Khess, Dr. Jalandhar Mehra INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-5 | May-2020


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