Nasal Carriage of Methicillin Resistant Staphylococci with Inducible Clindamycin Resistance and Pvl Gene.

SK.Jasmine Shahina; Sheeba Ali Siddiqui; Dr. Padma Krishnan

Volume : III, Issue : VI, June - 2014

Nasal Carriage of Methicillin Resistant Staphylococci with Inducible Clindamycin Resistance and Pvl Gene.

Sk. Jasmine Shahina, Sheeba Ali Siddiqui, Dr. Padma Krishnan

Abstract :

Anterior nares act as endogenous reservoir of S.aureus for clinical infections in the colonized individual and also as a source of cross-colonization for community spread in children. Clindamycin is used to treat staphylococcal skin and bone infections. Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide lincosamide and streptogramin antibiotics. Hence, this study was taken up to screen for inducible clindamycin resistance among carrier isolates of staphylococci from orphanage children. A total of 222 samples were collected from the anterior nares of asymptomatic orphanage children in the community from which 92 S.aureus and 48 coagulase negative staphylococci (CoNS) were isolated. 26/92 (28%) S.aureus were MRSA and 15/48 (31%) CoNS were resistant to methicillin. pvl genes were detected in 29 isolates of which 10 were from MRSA and 19 were from MSSA. 24/140 (17%) were of the inducible MLSB (iMLSB) phenotype. All the isolates showing D-positive were found harbouring ermC gene.