IJSR - International Journal of Scientific Research

Dr. Dinesh Khandelwal; Dr. Ashwini Hiremath; Dr. Kishor Kumar; Dr. R.S Jain; Dr. Trilochan Srivastava

Volume : VII, Issue : XII, December - 2018

NATIVE MEDICATION INDUCED ANTI-VGKC AUTOMMUNITY AND NEUROMYOTONIA:A case series of 4 patients from a tertiary care centre.

Dr. Dinesh Khandelwal, Dr. Ashwini Hiremath, Dr. Kishor Kumar, Dr. R. S Jain, Dr. Trilochan Srivastava

Abstract :

Isaac’s syndrome or Neuromyotonia is a disorder characterized by continuous muscle fiber activity with peripheral nerve hyperexcitability and typical electromyography features . The acquired form occur with autoimmune diseases, paraneoplastic syndromes and toxins. We describe 4 patients in whom Neuromyotonia was diagnosed after consumption of ayurvedic medications and was confirmed by presenting symptoms, physical examination , electrophysiologic findings and auto–antibody results. There could be suboptimal or undetectable levels of heavy metals/ elements triggering autoimmunity in these ayurvedic preparations. They expose VGKC channels on nerve endings leading to prolonged repolarization and Neuromyotonia. Immediate identification and withdrawl of drug is needed for amelioration of symptoms with prompt immunosuppressive therapy