Volume : IV, Issue : VIII, August - 2015

Neurohistological Effects of Lead on Cerebrum of Adult Albimo Rat

Dr S M Dawar Husain

Abstract :

LEAD is virtually toxic to almost every organ of body, including central nervous system. The present study is aimed to observe the histopathological changes in the cereum of rat induced by oral administration of lead compound in adult albino rats. A total number of 20 adult albino rats of either sex were included in the present study,consisting of equal numbers in both control and experimental groups. Experimental group received 4% aquous lead acetate orally for period of 15sdays., then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Cereum was dissected. 10µ thick sections were obtained by usual histological procedure andwere stained with Nissl stain. On light microscopic observation, cereum from experimental group revealedmultipolar neurons having shrunken soma. It was concluded that lead has toxic effects on the central nervous system including cereum which may explain the clinical manifestation of leadneurotoxicity

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr S M Dawar Husain Neurohistological Effectsof Lead on Cerebrum of Adult Albimo Rat International Journal of Scientific Research, Vol : 4, Issue : 8 August 2015

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