Volume : IV, Issue : VIII, August - 2015

NeurohistologicalEffects of Lead on Cerebellum of Adult Albimo Rat

Dr S M Dawar Husain

Abstract :

LEAD is toxic toevery organ of body, including central nervous system. This study is aimed to observe the histopathological changes in the cerebellum of rat induced by oral administration of lead compound in adult albino rats. A total number of 20 adult albino rats of either sex were included in the present study,consisting of equal numbers in both control and experimental groups. Experimental group received 4% aquous lead acetate orally for 15days., then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Cerebellum was dissected. 10µ thick sections were obtained by usual histological procedure and were stained with Nissl stain. Under light microscope, cerebellum from experimental group revealed loss of Nissl substance in the Purkinje cells and neurons with perineuralspace. It was concluded that lead has toxic effects on the central nervous system including cerebellum which may explain the clinical manifestation of leadneurotoxicity

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr S M Dawar Husain NeurohistologicalEffects of Lead on Cerebellum of Adult Albimo Rat International Journal of Scientific Research, Vol : 4, Issue : 8 August 2015

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