Neurohistopathological Effectsof Mercury on Cerebrum of Adult Albimo Rat S M Dawar Husain,Brajeshranjan, S.m. Yunus

Dr S M Dawar Husain; Dr BrajeshRanjan; S. M. Yunus

Volume : III, Issue : VII, July - 2014

Neurohistopathological Effectsof Mercury on Cerebrum of Adult Albimo Rat S M Dawar Husain,Brajeshranjan, S.m. Yunus

Dr S M Dawar Husain, Dr Brajeshranjan, S. M. Yunus

Abstract :

Mercury is virtually toxic to every organ of body, including central nervous system. The present study is aimed to observe the histopathological changes in thecereum of rat induced by oral administration of mercuric chloride in adult albino rats. A total number of 20 adult albino rats of either sex were included in the present study,consisting of equal numbers in both control and experimental groups. Experimental group received mercuric chloride in distilled water for a period of 15 days, then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Cereum was dissected. 10� thick sections were obtained by usual histological procedure and were stained with H&E. On light microscopic observation, cereum from experimental group revealed pleomorphic changes with pyknosis of nuclei, dense clustering with prominent spongiosis, multiple foci of necrosis with gliosis and congestion of blood capillaries with prominent perivascular fiosis. It was concluded that mercury has toxic effects on the central nervous system including cereum which may explain the clinical manifestation of mercury neurotoxicity.