Neurohistopathologicaleffects of Mercury on Cerebellum of Adult Albimo Rat

Dr S M Dawar Husain; Dr BrajeshRanjan; S. M. Yunus

Volume : III, Issue : VII, July - 2014

Neurohistopathologicaleffects of Mercury on Cerebellum of Adult Albimo Rat

Dr S M Dawar Husain, Dr Brajeshranjan, S. M. Yunus

Abstract :

Mercury is toxic to almost every organ of body, including central nervous system. The aim of present study is to observe the histopathological changes in the cerebellum of rat induced by oral administration of mercuric chloride in adult albino rats. A total number of 20 adult albino rats of either sex were included in the present study,consisting of equal numbers in both control and experimental groups. Experimental group received mercuric chloride in distilled water for aperiod of 15 days, then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Cerebellum was dissected out. 10� thick sections, obtained by usual histological procedure, were stained with H&E. On light microscopic observation, cerebellum from experimental group revealedmarked congestion of the blood capillaries with prominent perivascular fiosis. Cerebellum of experimental group also showed spongiosis in the molecular layer and markedly increased cellular granular cell layer with pyknotic nucleus. Few purkinje cells could be seen.It was concluded that mercury has toxic effects on the central nervous system including cerebellum which may explain the clinical manifestation of mercury neurotoxicity