Volume : III, Issue : I, January - 2014

Niosomes: Layered Delivery System For Drug Targeting

Surendra Agrawal, Vaishali Londhe, Ram Gaud

Abstract :

The main purpose of this review is to explore and overview the existing self dispersing formulations resulting from dilution of drug into emulsions, microemulsions and surfactant dispersions. The systematic approach used in preparation of niosome and the presentation of the various physico-chemical and biopharmaceutical aspects should facilitate the comprehension of this interesting field and clarify the main considerations involved in designing and characterizing a specific self dispersing drug delivery system. These Vesicular systems act as new drug delivery systems which enhance bioavailability as well as remedial activity of encapsulated drug in controlled manner. Niosomes formed from non-ionic surfactant vesicular system which can be easily formulated in the laboratory. Method of formulation, nature of surfactant, encapsulated drug temperature at which the lipids are hydrated and the packagings of niosomes play an effective and important role in the formulation of these vesicular systems. This vesicular system has unilamellar and multilamellar structures from the non-ionic surfactants and cholesterol. These are the bilayered structures in which hydrophilic as well as lipophilic drugs can be entrapped. This review article describes all aspects of niosomes including different composition, scalable techniques. Also it focuses on strength of formulation, limitations in respect to industrial applicability and regulatory requirements concerning the drug formulation based on FDA and EMEA documents. The review also provides detailed information of the various types of niosomes formulated for successful delivery by using different encapsulated drugs.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Surendra Agrawal, Vaishali Londhe, Ram Gaud Niosomes: Layered Delivery System For Drug Targeting International Journal of Scientific Research, Vol.III, Issue.I January 2014

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