Volume : VI, Issue : XII, December - 2017
Ondansetron induced QT interval changes in induction with isoflurane and halothane in healthy subjects undergoing general anaesthesia – A prospective, randomized, observer blind, controlled, parallel group study.
Prof Dr Sampa Dutta Gupta, Dr. Chhandasi Naskar, Dr. Smita Gogia, Dr. Aritra Bhattacharya, Dr. Sandipan Banerjee
Abstract :
SUMMARY: Many drugs administered to patients in the perioperative period are known to prolong Qtc like thiopentone, inhaled anaesthetics, ondansetron. Therefore we aimed to study ondansetron induced QT interval changes with isoflurane and halothane in healthy subjects undergoing general anaesthesia.
54 patients were divided randomly into three groups. Group C (control) received ondansetron, Group H (halothane) received ondansetron and halothane, Group I (isoflurane) received ondansetron and isoflurane. QTc and haemodynamic parameters were measured at baseline, immediately after giving ondansetron and five minutes (post induction) after giving ondansetron.
Five minutes after giving ondansetron there was a statistically significant prolongation of the QTc interval (QTc3) in Group C and Group I as compared to baseline (QTc1). QTc3 in group I showed statistically significant prolongation as compared to the group H.
So, concomitant use of isoflurane and ondansetron may prolong the QTc, predisposing to the development of arrhythmias.
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DOI : 10.36106/ijsr
Cite This Article:
Prof (Dr) Sampa Dutta Gupta, Dr.Chhandasi Naskar, Dr.Smita Gogia, Dr.Aritra Bhattacharya, Dr. Sandipan Banerjee, Ondansetron induced QT interval changes in induction with isoflurane and halothane in healthy subjects undergoing general anaesthesia‾A prospective, randomized, observer blind, controlled, parallel group study., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-12 | December-2017
Number of Downloads : 224
References :
Prof (Dr) Sampa Dutta Gupta, Dr.Chhandasi Naskar, Dr.Smita Gogia, Dr.Aritra Bhattacharya, Dr. Sandipan Banerjee, Ondansetron induced QT interval changes in induction with isoflurane and halothane in healthy subjects undergoing general anaesthesia‾A prospective, randomized, observer blind, controlled, parallel group study., INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-12 | December-2017
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