Oral Clonidine versus Gabapentin for Attenuation of Haemodynamic Surge during Endotracheal Intubation

Alipriya Banerjee; Rita Haldar (Dasgupta)

Volume : VIII, Issue : III, March - 2019

Oral Clonidine versus Gabapentin for Attenuation of Haemodynamic Surge during Endotracheal Intubation

Alipriya Banerjee, Rita Haldar Dasgupta

Abstract :

Objectives: 1.To compare the efficacy of oral clonidine 100 microgram and oral gabapentin 400 milligram for the attenuation of hemodynamic response to laryngoscopy and tracheal intubation under general anaesthesia by measuring pulse rate and blood pressure at specific intervals. 2. To find out the adverse effects after administration of study drugs. Materials and methods: 62 patients of ASA I receiving General Anaesthesia were randomised into two groups, Group C (n=31) received oral clonidine 100 mcg .Group G (n=31) received oral gabapentin 400mg two hours before intubation. Results: Clonidine prevented rise in Heart rate, Systolic, Diastolic and Mean Blood Pressure significantly throughout the first 15 minutes following laryngoscopy as compared to gabapentin group. Conclusion: oral clonidine 100mcg is a better premedicant than oral gabapentin 400mg in attenuating the hemodynamic responses to laryngoscopy and intubation. Adverse effects are minimal in both groups.